How We Score
How we vet the research — transparency first
How balanced proteasome regulation keeps cells healthy and extends lifespan
This elegant study shows that longevity pathways only work when your cells' protein-recycling machinery is properly balanced—a finding that could reshape how we design aging interventions, but needs replication in …
Genetic Markers of Healthy Aging: What Separates Long Life from Good Health in Old Age
This study identifies candidate genes linked to healthy aging in people over 90, but it's a genetic map, not a mechanism. The findings suggest aging is more complex than single-gene …
Why fasting works differently for different people: A genetic explanation
Genetics strongly influences how much intermittent fasting helps you live longer—a key insight that means people should expect different outcomes from the same fasting protocol. Before fasting is widely recommended, …
The Sleep Sweet Spot: How 6–8 hours connects to biological aging across your whole body
This preprint suggests a sweet spot of 6–8 hours of sleep for minimizing biological aging markers, but the findings are preliminary and require peer review and replication before influencing medical …
Some Anti-Aging Compounds Extend Male Worm Lifespan, But Not Always Reproductive Health
This worm study suggests that compounds extending lifespan don't automatically preserve all aspects of health—a useful reality check for anti-aging research. However, it's early-stage work in a simplified organism that …
How pregnancy ages some body systems while rejuvenating others—insights for slowing aging
Pregnancy provides a natural 'stress test' showing that some body systems can rejuvenate while others age—findings that challenge our assumptions about irreversible aging and could inspire new research directions, though …
Gut Bacteria Linked to Living Past 90: What Their Microbiomes Reveal
Centenarians have distinctly different and more beneficial gut bacteria than typical older adults, pointing to microbiota composition as a possible lever for healthy aging. However, this is an early correlational …
Urolithin A and cardiovascular health: preclinical promise meets human biomarker data
Urolithin A is a promising compound with solid preclinical evidence and early human data showing cardiovascular biomarker improvements, but the evidence is still preliminary—based on surrogate markers rather than proven …
NAD Precursors: What Science Says About NR vs NMN Supplements
NAD+ is genuinely important for cellular health, but the claim that NR supplements are superior to NMN or provide major exercise benefits in healthy people goes beyond current evidence. Rely …
A brain protein that declines with age may hold clues to extending lifespan
This is early-stage but promising research identifying a brain protein that extends fruit fly lifespan. It's a solid proof-of-concept using innovative methods, but it's premature to expect human applications—many candidate …
How Exercise Clears Damaged Cells and Reverses Muscle Aging
Exercise likely does help clear damaged cells from muscle tissue and improve metabolic health, which aligns with solid longevity science, but this Reddit post is an enthusiastic summary of a …
Vigorous Exercise 50-150x More Powerful Than Light Activity for Longevity
A Nature-published study provides good evidence that vigorous exercise delivers greater health benefits per minute than lighter activity, but this Reddit summary overstates certainty by presenting dramatic risk reduction ratios …
Spermidine emerges as top longevity nutrient in 15-year study of 146 compounds
Spermidine in foods like beans and mushrooms shows a strong association with living longer, but this could mean either spermidine itself is beneficial or it's simply a marker of eating …
Reversing Blood Cell Aging by Fixing Lysosomal Dysfunction
Scientists found that aging damages lysosomes—cellular garbage disposals—in blood-forming stem cells, and blocking the enzyme that causes this damage restored youthful function in mouse cells. This is a promising mechanistic …
Can Polyphenol-Rich Foods Slow Epigenetic Aging?
Polyphenol-rich foods like green tea, turmeric, and berries showed a promising link to slower epigenetic aging in this pilot study, but the effect was modest and unproven—larger, independent trials are …
Cardiovascular Biomarkers Deep Dive: Mike Lustgarten's 2025 Blood Test #7
This is a thorough, well-documented personal health tracking effort that demonstrates how to contextualize blood test results against epidemiological evidence—valuable for self-monitoring enthusiasts, but not a substitute for medical evaluation. …
Mike Lustgarten's Self-Experiment: NAD+ and Homocysteine Supplementation
This is a well-documented personal experiment showing one person's biomarker changes from supplementation, characterized by admirable honesty about disappointing results—but it provides no evidence that this supplement protocol actually slows …
Self-Tracked Diet & Biological Age: One Man's 15-Year Younger Result
This is an impressive example of personal health tracking and self-experimentation, but one person's dietary correlations with biomarkers—especially weak correlations—are not strong evidence for what will work for you. The …
TMAO: Health Risks, Dietary Sources, and Personalized Tracking
TMAO is a real health marker worth monitoring, but the story is more nuanced than "avoid TMAO-containing foods"—your gut bacteria composition and intestinal health (driven by fiber, exercise, and aging) …