How We Score
How we vet the research — transparency first
Beta-Hydroxybutyrate: The Ketone Link to Longevity in Mice
This video presents interesting mouse data linking a ketone body (BHB) to longevity through caloric restriction and ketogenic diet, with plausible mechanistic explanations—but all evidence is pre-clinical and doesn't prove …
Visceral Fat Reduction and Lifespan: Mike Lustgarten's 3-Year Self-Tracking
Rodent studies show visceral fat removal extends lifespan; Lustgarten's personal data shows he maintains unusually low visceral fat for his age, but this is one person measured three times—not proof …
Dr. Conboy on Epigenetic Clocks: Misalignment, Noise, and What They Actually Measure
Dr. Conboy presents credible scientific criticism of epigenetic aging clocks, arguing they measure statistical patterns rather than true biological age and miss key aging hallmarks—viewers should understand this as expert …
NMN & NAD Supplements: Debunking the Anti-Aging Hype with Science
While early animal research made NAD-boosting supplements seem promising, rigorous follow-up studies show they don't extend lifespan in mice or improve symptoms in humans, even when they successfully raise NAD …
Castration & Lifespan: What the Science Actually Shows About Testosterone
While castration does extend lifespan in animals and historical eunuchs, the real lesson isn't 'lower your testosterone'—it's that excessive growth signaling may drive aging, and that healthy testosterone levels remain …
Vigorous Exercise May Be 4-10x More Effective Than Moderate Activity
While this video raises a valid point—that current exercise guidelines are based on calorie burn rather than health outcomes—the lack of citation for the key study makes it impossible to …
Exercise, Heat, and Cold: Dr. Patrick's Healthspan Optimization Guide
This is a well-credentialed scientist presenting solid evidence that vigorous exercise is one of the most powerful life-extending interventions available; the core claims align with peer-reviewed science, though some study …
Seed Oils and Longevity: Evidence-Based Analysis of Nutritional Harm Claims
This episode attempts a rigorous, transparent examination of whether seed oils are uniquely harmful, with commendable disclosure of potential biases and a novel format to reduce unverified claims—but the absence …
Seed Oils vs. Lard: What the Science Actually Shows
Both seed oils and lard are bad when used for frying because fried foods are calorie-dense junk; the choice between them matters far less than avoiding regular consumption. Don't fall …
r/longevity Introductory Guide: Resources for Aging Biology Research
This is a well-curated introductory resource for understanding legitimate aging biology research, appropriately warning against quackery while directing readers to peer-reviewed papers and academic institutions. It's an excellent starting point …
Women's Hormones and Alzheimer's Risk: New Understanding of Brain Health in Menopause
This is a credible, well-informed conversation about detecting Alzheimer's disease before symptoms appear—an important topic for brain health. However, viewers should note that specific studies and evidence aren't cited in …
Women's Alzheimer's Prevention: Lifestyle, Menopause, and Emerging Treatments
This is a credible, measured discussion by an Alzheimer's researcher emphasizing that consistent lifestyle habits (exercise, sleep, nutrition, stress management) are the proven foundation of dementia prevention for women, with …
Why Women Develop Alzheimer's Earlier: Brain Changes Begin in Midlife
Women appear to develop Alzheimer's-related brain changes earlier than men starting in midlife, which may explain why Alzheimer's affects more women overall—but this is based on neuroimaging research that needs …
Oral Microbiome's Link to Alzheimer's Disease: New Research
This video presents an interesting emerging hypothesis that oral bacteria imbalance may contribute to Alzheimer's through inflammatory pathways, supported by publication in a respected journal. However, the actual evidence from …
Beta-2-Microglobulin and Neurogenesis: What's My Data?
Beta-2-microglobulin shows promise as a biomarker linked to brain health and aging, with solid mouse studies and intriguing human associations, but human causality remains unproven. Lustgarten's personal tracking is methodologically …
NAD+ Biology and Aging: Expert Insights on Boosting NAD Levels
NAD is genuinely important for cellular function, but the popular claim that "NAD declines with age" in healthy people is overstated—disease and metabolic problems are more reliable drivers of NAD …
High-Dose Creatine for Brain Function: 2024 Study Breakdown and Dosing Insights
While this post cites real creatine research and legitimately debunks safety myths, the recommendation to increase dosing to 15-20g/day for cognitive benefits lacks sufficient peer-reviewed support and exceeds conventional safety …
What Blood Biomarkers Predict Living to 100? Insights from Swedish Centenarian Study
A high-quality Swedish study found that certain blood biomarker patterns in middle age—including higher cholesterol and iron, lower blood sugar and kidney markers—were associated with living to 100, but this …
1,500 Days Sober: Biomarkers Show Dramatic Health Recovery After Alcoholism
This is an inspiring personal recovery story with impressive current biomarkers, but the dramatic health improvements cannot be scientifically proven without before/after data, comparison groups, and independent lab verification. The …
Genetics May Account for 50% of Lifespan, New Study Suggests
While the genetic contribution to lifespan is a legitimate research question, this post cites an unverifiable study without sufficient detail to evaluate its claims. Readers should be cautious about the …