How We Score
How we vet the research — transparency first
Life Expectancy Gains Are Slowing—Here's Why
Life expectancy improvements in wealthy countries are genuinely slowing because we've nearly eliminated infant and childhood deaths—the easy wins of the 20th century. Future improvements will require new medical breakthroughs …
DMTF1 Gene May Reverse Brain Aging in Neural Stem Cells
Researchers found a gene (DMTF1) that may help aging brain stem cells divide better by controlling chromatin structure, offering a potential drug target—but this is early-stage cellular research with no …
Horvath's Epigenetic Clocks: Measuring and Reversing Aging
Horvath's epigenetic clocks are real, peer-reviewed scientific tools that can measure biological age—a genuine advance in aging research. However, this discussion lacks evidence that measuring aging translates to reversing it, …
Does Ginseng Slow Aging? A Small Study on Telomeres and Cellular Energy in Middle-Aged Adults
Ginseng showed associations with longer telomeres and better aging markers in this small uncontrolled study, but without a placebo group or independent replication, these findings are preliminary and could reflect …
How Mild Calorie Restriction Rewires Brown Fat to Stay Energetic
Mild calorie restriction rewires brown fat to work more efficiently—not by burning out, but by adapting its metabolism while preserving its heat-generating power. This is a mechanistic clue about why …
How aging immune cells drive aging throughout the body
This is an authoritative but not definitive review explaining why your immune system's aging is a central driver of whole-body aging—and why fixing it could be unexpectedly powerful for extending …
Can crocin-enriched tomatoes slow aging and protect the brain?
This fruit fly study suggests crocin-enriched tomatoes may protect aging brains by supporting mitochondria, but much more work—especially human studies—is needed before we can say whether eating these tomatoes will …
How healthy diets add years to your life—even if your genes say otherwise
Multiple healthy dietary patterns—Mediterranean, plant-based, DASH, and others—consistently added 1.5–3 years of life expectancy in a large study, and these benefits occurred regardless of whether people carried genetic variants linked …
How to Reverse Age-Related Immune System Decline
This is a well-informed roadmap of how to potentially reverse immune aging by restoring the thymus gland, but it's mostly a survey of promising ideas rather than proof of what …
A Protein That Blocks Exercise Benefits: Why Some People Don't Respond to Training
This preprint identifies an intriguing protein that may explain why some people gain fitness from exercise while others don't—a finding with potential longevity implications. However, it's early-stage research that needs …